Results
| PMID | 25773531 |
| Gene Name | CYP19A1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 81 |
| Population details | 81 (40 infertile patients who received the indication of assisted reproduction techniques solely because of the presence of endometriosis, 41 patients whose procedure was indicated exclusively owing to the presence of male-factor infertility, tubal-factor infertility, or both) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Reprod Biomed Online. 2015 May;30(5):532-41. doi: 10.1016/j.rbmo.2015.01.012. Barcelos, Ionara Diniz E S| Donabella, Flavia Capello| Ribas, Cristiana Padovan| Meola, Juliana| Ferriani, Rui Alberto| de Paz, Claudia Cristina Paro| Navarro, Paula A Department of Gynecology and Obstetrics, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil.| Department of Gynecology and Obstetrics, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, B Aromatase plays a fundamental role in the establishment of oocyte quality, which might be compromised in infertile women with endometriosis. The expression of the CYP19A1 gene (that encodes aromatase) was compared in cumulus cells and oestradiol concentrations in the follicular fluid of infertile women with and without endometriosis submitted to ovarian stimulation for intracytoplasmic sperm injection. Cumulus cells were isolated and the expression of the CYP19A1 was quantitated through real-time polymerase chain reaction. Oestradiol concentrations in follicular fluid were measured by chemiluminescence immunoassay. A lower expression of the CYP19A1 in the cumulus cells of infertile women with endometriosis was observed compared with controls (0.17 +/- 0.13 and 0.56 +/- 0.12, respectively), and no significant difference in the follicular fluid oestradiol concentrations was observed between groups. Our results show reduced expression of the CYP19A1 in cumulus cells of infertile women with endometriosis, which may play a role in the pathogenesis of endometriosis-related infertility. Mesh Terms: Aromatase/*genetics| Case-Control Studies| Cumulus Cells/*enzymology| *Down-Regulation| Endometriosis/complications/*genetics| Female| Humans| Infertility, Female/complications/*genetics| Ovulation Induction| Pregnancy| Pregnancy Rate| Prospect |
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